If you decide on IVF: how to improve the quality of eggs and increase the chances of conception?

IVF, or in vitro fertilization, has been used in the world for over 40 years. For many couples, this is the only way to finally become parents. IVF can help even the most seemingly hopeless cases.

According to this technique, the female egg is removed from the body and artificially fertilized, and after the first division cycles returns to the uterine cavity for natural gestation.

Despite the fact that over the past 20 years, the percentage of successful IVF has tripled, no one guarantees the success of the procedure. Pregnancy after the first procedure is diagnosed on average in 30-50% of cases, and this percentage is significantly reduced if a woman has any diseases.

Do not give up in case of failure. It is believed that the chances of successful conception grow the first four cycles of IVF, from cycle to cycle. But this does not mean that further attempts are absolutely useless - any fertility specialist will remember cases when his patients managed to conceive a baby after the fifth or even the tenth attempt.

Decades of practical experience have not allowed to make a complete list of factors that affect the effectiveness of artificial insemination. Nevertheless, some of these conditions are known and can be adjusted to increase the chances of success:

• the quality of female eggs and male sperm;
• endometrial thickness of the uterus;
• general health of parents;
• clinic where the procedure is planned.

Undoubtedly, the priority is the state of female and male germ cells. Therefore, at the first stage of the IVF procedure, stimulation, it is important to take care of improving the quality of the eggs.

The production of eggs in the female body continues at 30 and at 40 years of age, but their quality deteriorates with age, which makes it harder to conceive, and the risk of defects in a child increases.

According to statistics, in women under 35, the chance to get pregnant after an IVF procedure on the first attempt is about 60%. After 35 years, this indicator starts to decline - sex cells accumulate internal defects and reduce the ability to produce energy (which is important at the stage of ovulation). Because of this, the division of a fertilized egg can be disturbed or the development of an already formed embryo can stop.

In addition to the age factor, the quality of the eggs is affected by:

• chronic diseases
• bad ecology in the place of permanent residence
• chronic stress
• Unhealthy Lifestyle
• frequent x-ray exposure in childhood
• hormonal disorders and thyroid function.

It takes about three months for the egg to mature, at which time it is particularly vulnerable to the effects of toxins and is very sensitive to nutrient deficiencies. Any violation reduces the chances of a healthy embryo being formed. Therefore, it is better to start taking care of the health of the germ cells as soon as a decision is made on the IVF procedure.

At the stage of ovulation stimulation, it is recommended to adhere to proper nutrition, remove fried and spicy foods, pickles, legumes from the diet, and sweetness and flour when prone to fullness. From physical exertion, it is necessary to leave sparing types like walking or yoga, temporarily abandon the sauna and bath, and also avoid hypothermia. For the prevention of the symptom of hyperstimulation, an enhanced drinking regime is recommended - up to 3 liters per day of non-carbonated water or fruit drink without the addition of sugar. It is clear that cigarettes and alcohol during this period must be forgotten.

In order to stimulate the maturation of several follicles at once, injections and intake of certain drugs are prescribed. An effective way to increase the quantity and quality of ova is to include such tools as Pregnoton and Synergin in the integrated preparation.

As shown by clinical studies "Pregnoton" helps to increase the number of mature eggs by 37%, embryos received - three times (8), and reduce the dose of hormonal drugs to stimulate ovulation. The composition of "Pregnoton" includes the daily rate of vitamins and minerals necessary during the maturation of the egg:

• Folic acid, or vitamin B9. It is considered a "female vitamin", normalizes the process of maturation of eggs, improves their quality and the functioning of the reproductive system as a whole. Affects the digestibility of other B vitamins (1).
• L-arginine. Increases the response of the ovaries and endometrium, is actively used in the treatment of infertility.
• Vitamin B2 (riboflavin). Affects energy metabolism and fertility (2).
• Vitamin C. Increases the likelihood of pregnancy, has anti-inflammatory properties. (3)
• Vitamin E. Refers to fat-soluble vitamins, as an antioxidant protects the eggs from damage by free radicals. Helps maintain vitamin C in the body, improves tissue oxygen saturation.
• Iodine. Necessary for proper operation of the thyroid gland. It prevents the formation of ovarian cysts, hypotrophy of the corpus luteum. On average, it improves the fertility of oocytes by 20%. (four).
• Selenium. Like vitamin E, prevents damage to the eggs, improves their maturation. (five)

"Synergin" It is a powerful complex of six antioxidants that protect the egg from exposure to harmful environmental factors. In addition to the already mentioned vitamins C and E, this preparation contains two components important for proper maturation of the egg cell:

• Ubiquinone (Coenzyme Q10) involved in the production of intracellular energy. It has been proven that saturation of the follicular fluid with coenzyme Q10 promotes egg maturation (6).
• Beta carotene It has not only an antioxidant effect, but also improves the functioning of the ovaries, positively affecting the synthesis of progesterone within a few weeks after the start of administration (7).

We cannot fully control the process of conception, but it is in our power to do everything possible to protect our organism. The reward for these efforts will be the birth of a healthy and strong baby.

Interesting facts about ova:

• The egg cell is the largest cell in the human body, the only one that can be viewed without a microscope.
• After ovulation, the egg lives from 12 to 24 hours.
• In the ovaries can mature several eggs. And if not one, but two of them are fertilized, a multiple pregnancy occurs.
• Thanks to the achievements of modern medicine, it is possible to transfer the nucleus from one egg to another, which allows women with hereditary diseases to have healthy children.

Literature:

1. [Smith A. D., Kim Y. I., Refsum H. Is folic acid good for everyone? Am J ClinNutr. 2008; 87 (3): 517-533].
2. [Dumollard R., Ward Z., Carroll J., Duchen M. R. Regulation of redox metabolism in the mouse oocyte and embryo. Development. 2007 Feb; 134 (3): 455-65].
3. [Jenkins, T. G., Aston K. I., Carrell, D. T. Supplementation of improved human sperm post-thaw motility, ascorbic acid-2-glucoside (AA2G). FertilSteril. 2011; 95: 2001–2004. ].
4. [Rodzaevskaia E. B. Morphological impairment of oogenesis in experimental iodine-dependent thyroid transformation. ArkhPatol. 2002 Mar-Apr; 64 (2): 10–3. ].
5. [Mirone M., Giannetta E., Isidori A. M. Selenium and reproductive function. A systematicreview. J EndocrinolInvest. 2013 Nov; 36 (10): Suppl: 28–36. ]
6. [Turi A. 1., Giannubilo SR, Brugè F., Principi F., Battistoni S., Santoni F., Tranquilli AL, Littarru G., Tiano L. Coenzyme Q10 . ArchGynecolObstet. 2012 Apr; 285 (4): 1173–].
7. [Arellano-Rodriguez G. 1., Meza-Herrera CA, Rodriguez-Martinez R., Dionisio-Tapia R., Hallford DM, Mellado M., Gonzalez-Bulnes A. Short-term intake of beta-carotene-supplemented diets enhances ovarian function and progesterone synthesis in goats.J AnimPhysiolAnimNutr (Berl). 2009 Dec; 93 (6): 710–5. ].
8. Serebrennikova KG, Kuznetsova E. P., Vanke E. S., et al. Pregravid training in patients with fine endometrium in assisted reproductive technology programs // Obstetrics and Gynecology. - 2017. - № 3.